A Prospective Study on Analysis of Ca15-3 in Breast Cancer Patient as a Prognostic Marker Shrivastava Vaibhav, Ghanghoria Arvind, Mandloi Deepak. Ghanghoria shikha,

Objective: To evaluate the role of cancer antigen CA15-3 as prognostic marker in breast cancer patient. Methods: The prospective study was done from November 2013 to October 2014 at Deparment of surgery, MGM Medical college and M.Y. Hospital group, Indore.This was a prospective study done on 31 patients with breast cancer. Blood samples were collected from all the patients and from the other patient also. Another samples of blood were collected from all these patients of breast cancer after two to three month to evaluate the relation between level of CA15.3 with breast cancer. Results: Raised value of tumor marker CA15-3 is seen with advanced stage of breast cancer .i.e. our data shows mean level of CA15-3 in stage I is 2 U/ml, stage II is 14.92 U/ml , stage III is 34 U/ml and stage IV is 59.6 U/ml. Initial value of CA15-3 significantly predict the response to treatment (i.e. primary/neoadjuvent chemo therapy/ surgery). Response to PC with high value of CA15.3 in stage III is 1/5 i.e.20% & in stage IV is 0/5 i.e 0% and with low value of CA15-3 in stage III is 6/7 i.e. 85.7% & in stage IV is 0%. 28 out of 31 pt. operated rest 3 cases are inoperable, 24 pt. showed fair response(i.e. no recurrence no progression of disease) and four pt. had disease recurrence after surgery with high level of CA15-3 Conclusion: As the raised value of CA15-3 is also found in other conditions other than Ca breast, as proven by other study so it could not be used as screening tool but as far as prognosis concern it can used as prognostic marker on serial intervals in advanced stage of breast cancer.